CD Genomics provides Human and Mouse Genome CGH Microarrays identifying DNA copy number variations associated with diseases and phenotypes.
DNA copy number variants (CNVs) are one of the important genetic variants, and some defects will affect gene expression and function. The human genome has about 6.7 × 104 CNVs, ranging in size from 1 kb-3 Mb, with a coverage of 5% -10% on the genome. Compared to single nucleotide polymorphisms (SNPs), CNVs involve more genomic sequences and possess a higher mutation rate. Therefore, CNV is not only a genetic polymorphism, but can cause major diseases such as birth defects, such as Alzheimer's disease, Crohn's disease and tumors. However, obtaining copy number information from large plant and animal genomes is much more difficult than from bacteria and yeast, because of the complex dynamics and genome composition.
CGH (comparative genomic hybridization) is an effective tool for detecting chromosomal abnormalities (deletions, duplications, or insertions of chromosome segments), and DNA CNVs, which can radiate the entire genome. CD Genomics applies hybridization and microarray technology to rapidly detect CNVs between multiple genetic samples (between different cells or between experimental groups and controls), to obtain visualization information of chromosomal aberrations, microduplication, and microdeletion. Microarray-based CGH has higher performance, compared to traditional hybridization techniques. Our CGH microarrays improve data coverage and resolution, produce stable, specific and quantitative hybridization signals with low noise and high resolution, and can be used to detect CNVs associated with diseases and phenotypes, as well as the role of hot spots in common diseases.
Our Advantages
- Detect aneuploidy and small fragment aberrations
- Detect triploidy and unbalanced tetraploidy
- Analyze heterogeneity of tumor samples
- Detect disease-associated CNVs
- CGH microarray products available for human, mouse and other species
- Custom CGH+SNP Microarray detecting CNVs and SNPs at s single assay
Workflow of our Microarray
Our CGH microarrays offer a quick and easy workflow. We also provide you with a one-stop CGH analysis service.
DNA Sample Requirements
- Amount: no less than 1 ug for each sample
- Concentration: 0.5-50 ng/µl
- Purity: OD260/280 should be 1.7 ~ 1.9
- Quality: genome should be integral, no degradation, no RNA contamination or other genomic DNA contamination
- Preservation and transportation: samples should be transported at low temperature (- 20℃) and sealed with sealing film to prevent contamination
CD Genomics is committed to providing a comprehensive range of microarray products and services to customers from around the world. We also provide custom CGH microarrays based on microarray technology, including human, mouse and rat microarrays, and custom CGH+SNP Microarray according to your needs. If you would like more information, please contact us.
