PDX Model Tissue Array Service
CD Genomics is a world-leading company that can provide the best solutions for global customers in the field of microarrays. We have successfully completed many scientific research and non-clinical research projects to ensure that we provide the best products and services to customers all over the world.
PDX Model and TMAs Technology
Patient-derived xenograft (PDX) cancer models are a rookie in the field of tumor research, opening up new animal models for tumor research. PDX models constructed using immunodeficient mice are widely used in tumor research, targeted cancer therapy research, and cancer drug development. After inserting human cancer tissue into the mouse microenvironment, both human and mouse-derived molecules can promote the proliferation and invasion of implanted tumor cells. The construction cost of the PDX model is relatively high. Combining TMA technology can greatly improve the utilization rate of the model tissue samples. Such tissue array products can be used for clinical research in oncology and immuno-oncology. TMA containing duplicates of tissue samples from the PDX model can be combined with specific fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) experiments for dual-labeled species (human and mouse) to characterize the number of important tumor-specific phenotypic markers. The tissue microarray derived from the PDX model is a special tumor tissue microarray product.
Fig 1. Work flow from PDX model preparation to tissue array.
PDX Model and TMAs Service
Our PDX model tissue sample library provide a variety of prefabricated formalin-fixed, paraffin-embedded (FFPE) TMA samples. The pre-made PDX tissue array products include a series of models covering specific tumor types. A single model array or multiple combined tissue array products for lung, liver, esophagus, colon and other tumor types. You can choose to customize our PDX personalized array products, or you can choose the corresponding testing services to quantitatively and qualitatively detect specific biomarkers of different tumor types. Our existing sample library contains more than 500 PDX models. If you are interested, please email us for consultation.
Fig 2. The tissue microarray service process of the PDX model of Bio-microarray.
Technical Advantages
- In order to reveal the in situ expression and spatial relationship of targeted molecules, explore the working mechanism of targeted therapy and evaluate its anti-cancer effects.
- It can quickly evaluate the performance of the tumor target of interest in a large number of tumor models, so as to quickly and effectively confirm whether there is a biomarker of interest in a large number of models.
- Hundreds of PDX models can be tested at the same time, greatly reducing the workload and improving the model screening process before transitioning to the in vivo efficacy experiment.
Our Features
- We have the world's leading supplier of PDX animal models;
- A variety of tumor types are available;
- Various specifications of microarrays are suitable for various detection experiments.
CD Genomics provides high-quality PDX model tissue array services. We have a well-equipped experimental platform, a large and professional team of scientists, and we are committed to cooperating with researchers from all over the world to meet the needs of our customers. Customers can contact our employees directly and provide timely feedback on their queries. If you are interested in our one-stop solution service, please contact us for more detailed information.
Reference
- Gymnopoulos M, Betancourt O, Blot V, et al. TR1801‐ADC: a highly potent cMet antibody–drug conjugate with high activity in patient‐derived xenograft models of solid tumors[J]. Molecular oncology, 2020, 14(1): 54-68.
Our products and services are for research purposes ONLY. We do not perform any private testing services that are not for laboratory use.
